Does Meridia has the blood pressure lowering effect?

Meridia blood pressure effectMeridia (Sibutramine) is used to treat obesity related to diabetes, high cholesterol & blood pressure & should be used with reduced calorie diet. It regulates chemicals in the brain which reduce hunger or food cravings. Meridia is serotonin-norepinephrine reuptake inhibitor, in short, it’s SNRI.  It should not be used if suffering from liver or kidney disorder or planning to become pregnant.

Important safety information

Meridia should be used with caution and under doctor’s guidance. It causes dizziness or blurred vision so after taking Meridia avoid driving and other important tasks which require complete alertness. It may cause severe drowsiness if taken with alcohol. For a successful weight loss, program dietary habits must be changed to a healthy diet and increased exercise. Meridia must not be used in children, elderly people & the patients having a heart problem or history of heart attack. The medication should not be used with another person. Consult your doctor if it does not improve your condition.

Blood pressure lowering effect

Over the past two decades, obesity prevalence has increased dramatically and has become a major public health concern.

Since its launch, it was seen that buying cheap Meridia online it is seen that it increases the blood pressure & this property acts as the major barrier for people with cardiovascular disease to use it. Many evidence has emerged over the past few years that it may increase the blood pressure in those patients which have normal blood pressure but its overall effect is just the opposite. As the majority of patients with moderately elevated blood pressure experienced fall in their blood pressure after taking Meridia treatment. But the concern is when Meridia is used in patients with poorly controlled blood pressure what happen to blood pressure.

A six-week placebo controlled double blind study was performed on overweight & cardiovascular disorder suffered patients. During 6 week time period, 10,742 patients were given Meridia & weight management. Vital sign changes assessed categorized as normal having systolic blood pressure less than 130 & diastolic less than 85. In high to normal systolic pressure is 130 to 140 & diastolic pressure is 85 to 90 & in hypertensive patients the pressure is greater than 140 as systolic and greater than 90 as diastolic pressure. Weight change categories are weight gain or no weight change that is less than 0 to 2.5% weight loss, >2.5 to 5% weight loss or greater than 5% weight loss.

50% of patients were hypertensive & 26% were high normal at entry level. In hypertensive patients blood pressure decreases that is -6.5 systolic & -2 diastolic. And there is a median decrease of -3.5 systolic pressure & -1.5 diastolic blood pressures in hypertensive patients with neither weight loss nor weight gain. 1.5 systolic & 1.0 diastolic pressure increases in normotensive patients. At the end point, 43% patients had lower blood pressures which were initially categorized as hypertensive.

Conclusion

During 6 week treatment with Meridia decrease in blood pressure was observed in hypertensive patients when body weight was unchanged. Patients having normal blood pressure, weight loss of greater than 5% cause a decrease in systolic pressure. Regardless of blood pressure or weight changes small pulse rate increase were observed.